The question of how cell-to-cell differences in transcription rate affect RNA count
distributions is fundamental for understanding biological processes underlying transcription …

The chemical master equation (CME) is a fundamental description of interacting molecules
commonly used to model chemical kinetics and noisy gene regulatory networks. Exact time …

In quantitative analyses of biological processes, one may use many different scales of
models (eg spatial or non-spatial, deterministic or stochastic, time-varying or at steady-state) …

Topic Areas: Novel Algorithms, Trustworthy AI, Foundation Models. Challenge: Interpretable
AI models for mechanism discovery in natural and synthetic gene regulatory systems. This …

The interpretation of transcriptomic observations requires detailed models of biophysical
noise that can be compared and fit to experimental data. Models of intrinsic noise …

Molecular systems biology constitutes a holistic approach towards understanding
mechanisms of the cell functioning. Cell signaling is one of the examples of self regulation …