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Genetically predicted type 2 diabetes mellitus mediates the causal association between plasma uric acid and ischemic stroke
C Wang, Y Gao, D Smerin, X **ong, Z Chen… - International …, 2024 - Elsevier
Objective This study conducts a systematic investigation into the causal relationships
between plasma uric acid levels and subtypes of ischemic stroke (IS), as well as the extent …
between plasma uric acid levels and subtypes of ischemic stroke (IS), as well as the extent …
The causal relationship between 5 serum lipid parameters and diabetic nephropathy: a Mendelian randomization study
H Liu, X Yao, L Wang, J Liu, X Li, X Fu, J Liu… - Frontiers in …, 2024 - frontiersin.org
Background Serum lipids were found to be correlated with chronic kidney disease and
cardiovascular disease. Here, we aimed to research the potential causal associations …
cardiovascular disease. Here, we aimed to research the potential causal associations …
Genetically predicted lipids mediate the association between intrahepatic cholestasis of pregnancy and cardiovascular disease
J Cui, Q Zhai, M Chen, Z Yang - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Introduction Intrahepatic cholestasis of pregnancy (ICP), the most prevalent liver disorder
specific to pregnancy, affects approximately 1.5%-4% of pregnancies. However, the …
specific to pregnancy, affects approximately 1.5%-4% of pregnancies. However, the …
Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in autoimmune rheumatic diseases: a brief research report from a …
X Xu, X Xu, MA Zakeri, SY Wang, M Yan… - Frontiers in …, 2024 - frontiersin.org
Background Currently, the association between the consumption of polyunsaturated fatty
acids (PUFAs) and the susceptibility to autoimmune rheumatic diseases (ARDs) remains …
acids (PUFAs) and the susceptibility to autoimmune rheumatic diseases (ARDs) remains …
Association of the gut microbiome and different phenotypes of COPD and asthma: a bidirectional Mendelian randomization study
Z Wang, J Qu, C Chang, Y Sun - Microbiology Spectrum, 2024 - journals.asm.org
Mounting evidence has revealed the association between gut microbiota and both chronic
obstructive pulmonary disease (COPD) and asthma; however, the causal association …
obstructive pulmonary disease (COPD) and asthma; however, the causal association …
Causal validation of the relationship between 35 blood and urine biomarkers and hyperthyroidism: a bidirectional Mendelian randomization study and meta-analysis
W Xu, J Wu, D Chen, R Zhang, Y Yang - Frontiers in Endocrinology, 2024 - frontiersin.org
Background Hyperthyroidism is an endocrine disorder with a relatively low global
prevalence but significantly higher incidence among females compared to males. The onset …
prevalence but significantly higher incidence among females compared to males. The onset …
Causal relationships between gut microbiota, plasma metabolites, and HIV infection: insights from Mendelian randomization and mediation analysis
J Hu, J Hu, D Han - Virology Journal, 2024 - Springer
Objective Gut dysbiosis and metabolic abnormalities have been implicated in HIV infection.
However, the exact causal relationships among the gut microbiota, metabolites, and HIV …
However, the exact causal relationships among the gut microbiota, metabolites, and HIV …
Proteomic insights into the pathophysiology of hypertension-associated albuminuria: Pilot study in a South African cohort
Background Hypertension is an important public health priority with a high prevalence in
Africa. It is also an independent risk factor for kidney outcomes. We aimed to identify …
Africa. It is also an independent risk factor for kidney outcomes. We aimed to identify …
Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes
X Yao, X Cai, S Zhang, Y Yang, X Yang, W Ma… - Scientific Reports, 2025 - nature.com
This study aims to explore the causal relationships between serum uric acid level and
pulmonary arterial hypertension (PAH) using the Mendelian randomization (MR) approach …
pulmonary arterial hypertension (PAH) using the Mendelian randomization (MR) approach …
Pyridoxal 5′-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis
M Zhang, J Zhong, Y Peng, L Hao, B **ao - EPMA Journal, 2024 - Springer
Background Stroke is a leading cause of mortality and disability worldwide. Identifying
predictive biomarkers and modifiable risk factors is crucial for stroke prevention in the …
predictive biomarkers and modifiable risk factors is crucial for stroke prevention in the …