Histone variants are key players in sha** chromatin structure, and, thus, in regulating
fundamental cellular processes such as chromosome segregation and gene expression …

Higher order chromatin structure has an impact on all nuclear functions, including the DNA
damage response. Over the past several years, it has become increasingly clear that …

Oncogene-induced senescence is characterized by a stable cell growth arrest, thus
providing a tumor suppression mechanism. However, the underlying mechanisms for this …

Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains
of facultative heterochromatin, called s enescence-a ssociated h eterochromatin f oci …

Background & Aims Maintenance of the covalently closed circular HBV DNA (cccDNA) that
serves as a template for HBV transcription is responsible for the failure of antiviral therapies …

One of the most prominent features of cellular senescence, a stress response that prevents
the propagation of cells that have accumulated potentially oncogenic alterations, is a …

Cellular senescence is an irreversible proliferation arrest of primary cells and an important
tumor suppression process. Senescence is often characterized by domains of facultative …

Histone chaperones bind specific histones to mediate their storage, eviction or deposition
from/or into chromatin. The HIRA histone chaperone complex, composed of HIRA …

Herpes simplex virus 1 (HSV-1) latency establishment is tightly controlled by promyelocytic
leukemia (PML) nuclear bodies (NBs)(or ND10), although their exact contribution is still …

Abstract Heterochromatin protein 1 (HP1) is a positive regulator of active transcription in
euchromatin. HP1 was first identified in Drosophila melanogaster as a major component of …