Lindane, the γ-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified
lindane or unpurified mixtures of this and α-, β-, and δ-isomers of HCH were widely used as …

Mechanistic insight into the biochemistry of carbon–halogen bond cleavage is rapidly
growing because of recent structural, biochemical and computational studies that have …

Background The main aim of this study was to develop and implement an algorithm for the
rapid, accurate and automated identification of paths leading from buried protein clefts …

Engineering enzymes to degrade anthropogenic compounds efficiently is challenging. We
obtained Rhodococcus rhodochrous haloalkane dehalogenase mutants with up to 32-fold …

Novel dehalogenases have been identified recently in various bacteria that utilise
halogenated substrates. X-ray studies and sequence analysis have revealed insight into the …

Abstract γ-Hexachlorocyclohexane (γ-HCH, also called γ-BHC and lindane) is a
halogenated organic insecticide that causes serious environmental problems. The aerobic …

Transport of ligands between buried active sites and bulk solvent is a key step in the
catalytic cycle of many enzymes. The absence of evolutionary optimized transport tunnels is …

Our fundamental understanding of proteins and their biological significance has been
enhanced by genetic fusion tags, as they provide a convenient method for introducing …

The variety of halogenated substances and their derivatives widely used as pesticides,
herbicides and other industrial products is of great concern due to the hazardous nature of …

Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity,
substrate specificity, and stability, they require mild conditions to react while prompting …