Inositol trisphosphate is a second messenger that controls many cellular processes by
generating internal calcium signals. It operates through receptors whose molecular and …

Reactive oxygen species (ROS) are recognized both as damaging molecules and
intracellular signaling entities. In addition to its role in ATP generation, the mitochondrial …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

The goal of this review article is to assess how relevant is the concept of dissipative structure
for understanding the dynamical bases of non-equilibrium self-organization in biological …

Abstract Background Calcium (Ca 2+) oscillations are ubiquitous signals present in all cells
that provide efficient means to transmit intracellular biological information. Either …

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical
engineering and cell biology by lucidly and practically demonstrating how a mathematical …

All living cells use a network of signal transduction pathways to conduct developmental
programs, obtain nutrients, control their metabolism, and cope with their environment. A …

There is no doubt that nowadays, biology benefits greatly from mathematics. In particular,
cellular biology is, besides population dynamics, a field where tech niques of mathematical …

Intracellular calcium (Ca2+) is a ubiquitous second messenger. Information is encoded in
the magnitude, frequency, and spatial organization of changes in the concentration of …

Calcium signaling results from a complex interplay between activation and inactivation of
intracellular and extracellular calcium permeable channels. This complexity is obvious from …