Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years

E Alexander, KW Leong - Journal of Nanobiotechnology, 2024 - Springer
Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies
found in the Camelidae family as well as cartilaginous fish. Their unique structural and …

Next generation single-domain antibodies against respiratory zoonotic RNA viruses

IC Swart, W Van Gelder, CAM De Haan… - Frontiers in Molecular …, 2024 - frontiersin.org
The global impact of zoonotic viral outbreaks underscores the pressing need for innovative
antiviral strategies, particularly against respiratory zoonotic RNA viruses. These viruses …

Shark VNAR phage display libraries: An alternative source for therapeutic and diagnostic recombinant antibody fragments

K Manoutcharian, G Gevorkian - Fish & Shellfish Immunology, 2023 - Elsevier
The development of recombinant antibody fragments as promising alternatives to full-length
immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have …

Exploring shark VNAR antibody against infectious diseases using phage display technology

HT Lim, BH Kok, CY Leow, CH Leow - Fish & Shellfish Immunology, 2023 - Elsevier
Antibody with high affinity and specificity to antigen has widely used as a tool to combat
various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) …

Heterologous Expression, Characterization, and Fish Matrix Performance of a Shark-Derived Single-Domain Antibody Fusion Protein against Enrofloxacin

C Liu, H Lin, L Cao, K Wang, J Sui - 2023 - researchsquare.com
The abuse of enrofloxacin (ENR) in aquaculture and the lack of monitoring of other
metabolites may lead to unknown harmful effects on human health. In this study, a shark …