Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

The human brain is a large-scale integrated network in the functional and structural domain.
Graph theoretical analysis provides a novel framework for analysing such complex …

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Consciousness is essential to normal human life. In epileptic seizures consciousness is
often transiently lost, which makes it impossible for the individual to experience or respond …

The cellular mechanisms underlying typical absence seizures, which characterize various
idiopathic generalized epilepsies, are not fully understood, but impaired γ-aminobutyric acid …

Abstract We identified 15q13. 3 microdeletions encompassing the CHRNA7 gene in 12 of
1,223 individuals with idiopathic generalized epilepsy (IGE), which were not detected in …

Idiopathic generalized epilepsies account for 30% of all epilepsies. Despite a predominant
genetic aetiology, the genetic factors predisposing to idiopathic generalized epilepsies …