Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …

Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …

PD-1 blockade unleashes potent antitumor activity in CD8+ T cells but can also promote
immunosuppressive T regulatory (Treg) cells, which may worsen the response to …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

T and B cells are key components of the adaptive immune system. Through their immune
properties and their interactions with other immune cells and cytokines around them, they …

Myelodysplastic syndromes/neoplasms (MDS) constitute a heterogeneous group of clonal
hematopoietic disorders with extremely variable clinical features and outcomes …

Immunotherapy, particularly that based on blocking checkpoint proteins in many tumors,
including melanoma, Merkel cell carcinoma, non-small cell lung cancer (NSCLC), triple …

This study aimed to identify hub genes involved in regulatory T cell (Treg) function and
migration, offering insights into potential therapeutic targets for cancer immunotherapy. We …

Bone metastases are a prevalent complication in advanced cancers, particularly in breast,
prostate, and lung cancers, and are associated with severe skeletal-related events (SREs) …

SUMMARY PD-1 blockade unleashes the potent antitumor activity of CD8 cells but can also
promote immunosuppressive T regulatory (Treg) cells, which may worsen response to …