A typical output of a metabolomic experiment is a peak table corresponding to the intensity
of measured signals. Peak table processing, an essential procedure in metabolomics, is …

Data normalization is a big challenge in quantitative metabolomics approaches, whether
targeted or untargeted. Without proper normalization, the mass-spectrometry and …

The papain-like protease PLpro is an essential coronavirus enzyme that is required for
processing viral polyproteins to generate a functional replicase complex and enable viral …

Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and
metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic …

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …

How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage
cellular host pathways and innate immunity in infected cells remains largely elusive. We …

Biological processes (like microbial growth & physiological response) are usually dynamic
and require the monitoring of metabolic variation at different time-points. Moreover, there is …

Acute lysosomal membrane damage reduces the cellular population of functional
lysosomes. However, these damaged lysosomes have a remarkable recovery potential …

Reproducible research is the bedrock of experimental science. To enable the deployment of
large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time …

In the rapidly moving proteomics field, a diverse patchwork of data analysis pipelines and
algorithms for data normalization and differential expression analysis is used by the …