Cells are equipped with a diverse network of signaling and regulatory proteins that function
as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell …

The centrosome is a non-membrane-bound organelle that is conserved across most animal
cells and serves various functions throughout the cell cycle. In dividing cells, the centrosome …

Mitotic centrosomes assemble when centrioles recruit large amounts of pericentriolar
material (PCM) around themselves. The PCM comprises hundreds of proteins, and there is …

Breast cancer is the most prevalent malignancy among women worldwide. Despite
significant advances in treatment, it remains one of the leading causes of female mortality …

Mitotic centrosomes assemble when centrioles recruit large amounts of pericentriolar
material (PCM) around themselves. In early C. elegans embryos, mitotic centrosome size …

Mitotic progression requires the precise formation of spindle microtubules based on mature
centrosomes. During the G2/M transition, centrosome maturation progresses, and …

Polo-like-kinase (PLK) 1 activity is associated with maintaining the functional and physical
properties of the centrosome's pericentriolar matrix (PCM). In this study, we use a multimodal …

Centrioles duplicate once per cell cycle, but it is unclear how daughter centrioles assemble
at the right time and place and grow to the right size. Here, we show that in Drosophila …

Maintaining a definite and stable pool of dividing stem cells plays an important role in organ
development. This process requires an appropriate progression of mitosis for proper spindle …

Centrioles are composed of a central cartwheel tethered to nine-fold symmetric microtubule
(MT) blades. The centriole cartwheel and MTs are thought to grow from opposite ends of …