Exhaled nitric oxide in pulmonary diseases: a comprehensive review

PJ Barnes, RA Dweik, AF Gelb, PG Gibson, SC George… - Chest, 2010 - Elsevier
The upregulation of nitric oxide (NO) by inflammatory cytokines and mediators in central and
peripheral airway sites can be monitored easily in exhaled air. It is now possible to estimate …

Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease

C Villanueva, C Giulivi - Free Radical Biology and Medicine, 2010 - Elsevier
The effects of nitric oxide in biological systems depend on its steady-state concentration and
where it is being produced. The organ where nitric oxide is produced is relevant, and within …

A European Respiratory Society technical standard: exhaled biomarkers in lung disease

I Horváth, PJ Barnes, S Loukides… - European …, 2017 - publications.ersnet.org
Breath tests cover the fraction of nitric oxide in expired gas (F ENO), volatile organic
compounds (VOCs), variables in exhaled breath condensate (EBC) and other …

Arginine therapy for lung diseases

JA Scott, H Maarsingh, F Holguin… - Frontiers in …, 2021 - frontiersin.org
Nitric oxide (NO) is produced by a family of isoenzymes, nitric oxide synthases (NOSs),
which all utilize l-arginine as substrate. The production of NO in the lung and airways can …

Assessment of small-airways disease using alveolar nitric oxide and impulse oscillometry in asthma and COPD

PA Williamson, K Clearie, D Menzies, S Vaidyanathan… - Lung, 2011 - Springer
The contribution of the alveolar compartment to exhaled nitric oxide (alveolar nitric oxide or
CA NO) can be calculated as a surrogate of distal inflammation. This value should be …

Association of multiple air pollutants with oxygen saturation during sleep in COPD patients: Effect modification by smoking status and airway inflammatory phenotypes

W Zhang, J Wang, B Chen, X Ji, C Zhao, M Chen… - Journal of Hazardous …, 2023 - Elsevier
Air pollution contributes substantially to the development of chronic obstructive pulmonary
disease (COPD). To date, the effect of air pollution on oxygen saturation (SpO 2) during …

Methods of NO detection in exhaled breath

SM Cristescu, J Mandon, FJM Harren… - Journal of Breath …, 2013 - iopscience.iop.org
There is still an unexplored potential for exhaled nitric oxide (NO) in many clinical
applications. This study presents an overview of the currently available methods for …

Partitioned exhaled nitric oxide to non-invasively assess asthma

JL Puckett, SC George - Respiratory physiology & neurobiology, 2008 - Elsevier
Asthma is a chronic inflammatory disease of the lungs, characterized by airway
hyperresponsiveness. Chronic repetitive bouts of acute inflammation lead to airway wall …

Bronchial nitric oxide is related to symptom relief during fluticasone treatment in COPD

L Lehtimäki, H Kankaanranta… - European …, 2009 - publications.ersnet.org
High levels of exhaled nitric oxide (NO) predict favourable response to inhaled
corticosteroids in asthma, but the ability of exhaled NO or inflammatory markers in exhaled …

Exhaled nitric oxide parameters and functional capacity in chronic obstructive pulmonary disease

MR McCurdy, A Sharafkhaneh… - Journal of Breath …, 2011 - iopscience.iop.org
The extended exhaled nitric oxide (eNO) parameters, including peripheral or alveolar eNO,
are investigational biomarkers in COPD. In this study, the hypothesis was tested that …