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The extracellular matrix of mycobacterial biofilms: could we shorten the treatment of mycobacterial infections?
A number of non-tuberculous mycobacterium species are opportunistic pathogens and
ubiquitously form biofilms. These infections are often recalcitrant to treatment and require …
ubiquitously form biofilms. These infections are often recalcitrant to treatment and require …
In vivo imaging with genetically encoded redox biosensors
Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …
both normal physiology and the pathogenesis of various diseases. However, this area of …
[HTML][HTML] MtrA modulates Mycobacterium tuberculosis cell division in host microenvironments to mediate intrinsic resistance and drug tolerance
The success of Mycobacterium tuberculosis (Mtb) is largely attributed to its ability to
physiologically adapt and withstand diverse localized stresses within host …
physiologically adapt and withstand diverse localized stresses within host …
Altered serine metabolism promotes drug tolerance in Mycobacterium abscessus via a WhiB7-mediated adaptive stress response
Mycobacterium abscessus is an emerging opportunistic pathogen responsible for chronic
lung diseases, especially in patients with cystic fibrosis. Treatment failure of M. abscessus …
lung diseases, especially in patients with cystic fibrosis. Treatment failure of M. abscessus …
Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis
Respiration is a promising target for the development of new antimycobacterial agents, with
a growing number of compounds in clinical development entering this target space …
a growing number of compounds in clinical development entering this target space …
Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and accumulation of reactive oxygen species
Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …
In Vivo NADH/NAD+ Biosensing Reveals the Dynamics of Cytosolic Redox Metabolism in Plants
J Steinbeck, P Fuchs, YL Negroni, M Elsässer… - Plant Cell, 2020 - academic.oup.com
NADH and NAD+ are a ubiquitous cellular redox couple. Although the central role of NAD in
plant metabolism and its regulatory role have been investigated extensively at the …
plant metabolism and its regulatory role have been investigated extensively at the …
Gene evolutionary trajectories in Mycobacterium tuberculosis reveal temporal signs of selection
Genetic differences between different Mycobacterium tuberculosis complex (MTBC) strains
determine their ability to transmit within different host populations, their latency times, and …
determine their ability to transmit within different host populations, their latency times, and …
Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting Mycobacterium tuberculosis type II NADH dehydrogenase
Mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase (NDH-2) transports
electrons into the mycobacterial respiratory pathway at the cost of reduction of NADH to …
electrons into the mycobacterial respiratory pathway at the cost of reduction of NADH to …
Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
Mycobacterium tuberculosis (Mtb) exhibits remarkable metabolic flexibility that enables it to
survive a plethora of host environments during its life cycle. With the advent of bedaquiline …
survive a plethora of host environments during its life cycle. With the advent of bedaquiline …