With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …

Pluripotency reprogramming and transdifferentiation induced by transcription factors can
generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the …

Pooled CRISPR screens are a powerful tool for assessments of gene function. However,
conventional analysis is based exclusively on the relative abundance of integrated single …

Direct reprogramming of fibroblasts to alternative cell fates by forced expression of
transcription factors offers a platform to explore fundamental molecular events governing cell …

Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) or directly
reprogrammed from non-myocytes (induced cardiomyocytes [iCMs]) are promising sources …

Cardiovascular disease, until now, is still the leading cause of death in the United States.
Due to the limited regenerative capacity of adult hearts, the damage caused by heart injury …

Ischemic heart disease is the leading cause of morbidity, mortality, and healthcare
expenditure worldwide due to an inability of the heart to regenerate following injury. Thus …

Specified intestinal epithelial cells reprogram and contribute to the regeneration and
renewal of the epithelium upon injury. Mutations that deregulate such renewal processes …

Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds great promise
for heart regeneration. Although considerable progress has been made in understanding …

Direct cardiac reprogramming to induce cardiomyocyte-like cells, eg, by GMT (Gata4, Mef2c
and Tbx5), is a promising route for regenerating damaged heart in vivo and disease …