Flavonoids a bioactive compound from medicinal plants and its therapeutic applications

A Roy, A Khan, I Ahmad, S Alghamdi… - BioMed research …, 2022 - Wiley Online Library
Plants generally secrete secondary metabolites in response to stress. These secondary
metabolites are very useful for humankind as they possess a wide range of therapeutic …

[HTML][HTML] Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

KM Yap, M Sekar, YS Wu, SH Gan, NNIM Rani… - Saudi Journal of …, 2021 - Elsevier
Breast cancer (BC) has high incidence and mortality rates, making it a major global health
issue. BC treatment has been challenging due to the presence of drug resistance and the …

Quercetin counteracts monosodium glutamate to mitigate immunosuppression in the thymus and spleen via redox-guided cellular signaling

D Das, A Banerjee, K Manna, D Sarkar, A Shil… - Phytomedicine, 2024 - Elsevier
Background Chronic inflammation brought on by oxidative stress can result in several
immunopathologies. Natural compounds with antioxidant characteristics, like quercetin …

Polyphenols as anticancer agents: Toxicological concern to healthy cells

B Islam, M Suhail, MK Khan, TA Zughaibi… - Phytotherapy …, 2021 - Wiley Online Library
Polyphenols are a group of diverse chemical compounds present in a wide range of plants.
Various biological properties such as antiallergic, antiviral, antibacterial, anticarcinogenic …

Targeting dysregulated intracellular immunometabolism within synovial microenvironment in rheumatoid arthritis with natural products

S Hu, Y Lin, Y Tang, J Zhang, Y He, G Li… - Frontiers in …, 2024 - frontiersin.org
Immunometabolism has been an emerging hotspot in the fields of tumors, obesity, and
atherosclerosis in recent decades, yet few studies have investigated its connection with …

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Y Peng, R Qu, S Xu, H Bi, D Guo - Heliyon, 2024 - cell.com
Naringin is a natural flavonoid with therapeutic properties found in citrus fruits and an active
natural product from herbal plants. Naringin has become a focus of attention in recent years …

Flavonoids attenuate cancer metabolism by modulating lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2

M Samec, A Mazurakova, V Lucansky… - European Journal of …, 2023 - Elsevier
Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation.
The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well …

Differential toxic and antiepileptic features of Vigabatrin raceme and its enantiomers

SL Xu, M Fan, MD Ma, Q Zheng, PQ Chen, YD Wei… - Brain Research, 2024 - Elsevier
Background The study aimed to investigate the potential pharmacological and toxicological
differences between Vigabatrin (VGB) and its enantiomers S-VGB and R-VGB. The …

Establishment of in-house assay for screening of anti-SARS-CoV-2 protein inhibitors

MH Emam, MI Mahmoud, N El-Guendy, SA Loutfy - AMB Express, 2024 - Springer
Develo** a potent antiviral agent to combat Coronavirus Disease-19 (COVID-19) is of
critical importance as we may be at risk of the emergence of new virus strains or another …

[HTML][HTML] Natural products as potential modulators of pro-inflammatory cytokines signalling in Alzheimer's disease

V Yadav, C Mythri, M Kumarasamy - Brain Behavior and Immunity …, 2024 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary
cause of dementia in the elderly population. Previous studies have suggested that …