Down syndrome (DS) is the most common genetic cause of mental disability. Based on the
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence.
Alternatively, cells enter senescence in response to inappropriate growth signals such as …

In adult mammals, neural stem cells (NSCs) generate new neurons that are important for
specific types of learning and memory. Controlling adult NSC number and function is …

Evidence in mouse models for Down syndrome (DS) and human fetuses with DS clearly
shows severe neurogenesis impairment in various telencephalic regions, suggesting that …

Mammalian cells have a remarkable capacity to compensate for heterozygous gene loss or
extra gene copies. One exception is Down syndrome (DS), where a third copy of …

Down syndrome (DS), commonly caused by an extra copy of chromosome 21 (chr21),
occurs in approximately one out of 700 live births. Precisely how an extra chr21 causes over …

Down syndrome (DS) is a genetic pathology caused by the triplication of human
chromosome 21. Although individuals with DS have various medical problems, intellectual …

Abstract Background The Ts1Cje mouse model of Down syndrome (DS) has partial
triplication of mouse chromosome 16 (MMU16), which is partially homologous to human …

People with Down syndrome (DS) exhibit abnormal brain structure. Alterations affecting
neurotransmission and signalling pathways that govern brain function are also evident. A …