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Sporadic Parkinson's disease: development and distribution of α‐synuclein pathology
K Del Tredici, H Braak - Neuropathology and applied …, 2016 - Wiley Online Library
The development of α‐synuclein immunoreactive aggregates in selectively vulnerable
neuronal types of the human central, peripheral, and enteric nervous systems is crucial for …
neuronal types of the human central, peripheral, and enteric nervous systems is crucial for …
Mitochondrial dysfunction in Parkinson's disease
HE Moon, SH Paek - Experimental neurobiology, 2015 - pmc.ncbi.nlm.nih.gov
Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons of
the substantia nigra pars compacta (SNc) with motor and nonmotor symptoms. Defective …
the substantia nigra pars compacta (SNc) with motor and nonmotor symptoms. Defective …
Basic mechanisms of neurodegeneration: a critical update
KA Jellinger - Journal of cellular and molecular medicine, 2010 - Wiley Online Library
Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlap**,
fatal neurodegenerative disorders in which the molecular and pathogenic basis remains …
fatal neurodegenerative disorders in which the molecular and pathogenic basis remains …
Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases
B Cauwe, G Opdenakker - Critical reviews in biochemistry and …, 2010 - Taylor & Francis
Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …
The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disease in
developed countries. The core motor symptoms are attributable to the degeneration of …
developed countries. The core motor symptoms are attributable to the degeneration of …
Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: implication for protein aggregation and immune response
The ubiquitin-proteasome system (UPS) is the major intracellular proteolytic mechanism
controlling the degradation of misfolded/abnormal proteins. A common hallmark in …
controlling the degradation of misfolded/abnormal proteins. A common hallmark in …
The promise and challenges of develo** miRNA-based therapeutics for Parkinson's disease
SS Titze-de-Almeida, C Soto-Sánchez, E Fernandez… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-
specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of …
specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of …
Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation
Autophagy is involved in the pathogenesis of neurodegenerative diseases including
Parkinson disease (PD). However, little is known about the regulation of autophagy in …
Parkinson disease (PD). However, little is known about the regulation of autophagy in …
SIRT3 protects rotenone-induced injury in SH-SY5Y cells by promoting autophagy through the LKB1-AMPK-mTOR pathway
M Zhang, YN Deng, JY Zhang, J Liu, YB Li… - Aging and …, 2018 - pmc.ncbi.nlm.nih.gov
SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability
and stress resistance. It has been implicated as a potential therapeutic target in a variety of …
and stress resistance. It has been implicated as a potential therapeutic target in a variety of …