The sexual dimorphism in human body fat distribution suggests a causal role for sex
hormones. This is of particular importance when considering the role of excess visceral …

Over the past decade, adipose tissues have been increasingly known for their endocrine
properties, that is, their ability to secrete a number of adipocytokines that may exert local …

Steroids are synthesized from the adrenal glands and gonads by enzymes of the
cytochromes P450 and hydroxysteroid dehydrogenase in nature. These enzymes are …

The superfamily of hydroxysteroid dehydrogenases (HSDs) has been well-characterized as
enzymes in lipid metabolism, and especially in steroid hormone metabolism from bacteria to …

The acute response to stress consists of a series of physiological programs to promote
survival by generating glucocorticoids and activating stress response genes that increase …

After cholesterol is transported into the mitochondria of steroidogenic tissues, the first
steroid, pregnenolone, is synthesized in adrenal and gonadal tissues to initiate steroid …

Dehydroepiandrosterone (DHEA, 2) is an important endogenous steroid hormone in
mammals used in the treatment of a variety of dysfunctions in female and male health, 1 as …

Steroidogenic factor 1 (SF‐1) is a master regulator for steroidogenesis. In this study, we
identified novel SF‐1 target genes using a genome‐wide promoter tiling array and a DNA …

The inner mitochondrial membrane protein 3β-hydroxysteroid dehydrogenase 2 (3βHSD2)
synthesizes progesterone and androstenedione through its dehydrogenase and isomerase …

Abstract Human 3-β-hydroxysteroid dehydrogenase/isomerase types 1 and 2 (3βHSD1 and
3βHSD2, respectively) are expressed in a tissue-specific pattern by different genes. Site …