Multisystem physiological perspective of human frailty and its modulation by physical activity

JA Taylor, PL Greenhaff, DB Bartlett… - Physiological …, 2023 - journals.physiology.org
“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Instruments for the detection of frailty syndrome in older adults: a systematic review

JW Faller, DN Pereira, S de Souza, FK Nampo… - PloS one, 2019 - journals.plos.org
Frailty is a dynamic process in which there is a reduction in the physical, psychological
and/or social function associated with aging. The aim of this study was to identify instruments …

[HTML][HTML] Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank …

P Hanlon, BI Nicholl, BD Jani, D Lee… - The Lancet Public …, 2018 - thelancet.com
Background Frailty is associated with older age and multimorbidity (two or more long-term
conditions); however, little is known about its prevalence or effects on mortality in younger …

Frailty and the prediction of negative health outcomes: a meta-analysis

S Vermeiren, R Vella-Azzopardi, D Beckwee… - Journal of the American …, 2016 - Elsevier
Introduction Frailty is one of the most important concerns regarding our aging population.
Evidence grows that the syndrome is linked to several important health outcomes. A general …

[HTML][HTML] Frailty and sarcopenia: the potential role of an aged immune system

D Wilson, T Jackson, E Sapey, JM Lord - Ageing research reviews, 2017 - Elsevier
Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of
muscle mass, quality and strength, is more common in older adults and has been …

Frailty assessment instruments: systematic characterization of the uses and contexts of highly-cited instruments

BJ Buta, JD Walston, JG Godino, M Park… - Ageing research …, 2016 - Elsevier
The medical syndrome of frailty is widely recognized, yet debate remains over how best to
measure it in clinical and research settings. This study reviewed the frailty-related research …

Effectiveness of exercise interventions on physical function in community-dwelling frail older people: an umbrella review of systematic reviews

AD Jadczak, N Makwana… - JBI Evidence …, 2018 - journals.lww.com
Objectives: This umbrella review aimed to determine the effectiveness of exercise
interventions, alone or in combination with other interventions, in improving physical function …

Differences in handgrip strength protocols to identify sarcopenia and frailty-a systematic review

AR Sousa-Santos, TF Amaral - BMC geriatrics, 2017 - Springer
Background Hand grip strength (HGS) is used for the diagnosis of sarcopenia and frailty.
Several factors have been shown to influence HGS values during measurement. Therefore …

Agreement between 35 published frailty scores in the general population

GA Aguayo, AF Donneau, MT Vaillant… - American journal of …, 2017 - academic.oup.com
In elderly populations, frailty is associated with higher mortality risk. Although many frailty
scores (FS) have been proposed, no single score is considered the gold standard. We …

Effects of multi-domain interventions in (pre) frail elderly on frailty, functional, and cognitive status: a systematic review

L Dedeyne, M Deschodt, S Verschueren… - … interventions in aging, 2017 - Taylor & Francis
Background Frailty is an aging syndrome caused by exceeding a threshold of decline across
multiple organ systems leading to a decreased resistance to stressors. Treatment for frailty …