Nucleic acid is the main material for storing, copying, and transmitting genetic information.
Gene sequencing is of great significance in DNA damage research, gene therapy, mutation …

Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of
kynurenic acid, anthranilic acid and 3-hydroxykynurenine (3-HK). Under physiological …

Conventional type 1 dendritic cells (cDC1) are critical for antitumor immunity, and their
abundance within tumors is associated with immune-mediated rejection and the success of …

Abstract Background Circular RNAs (circRNAs) play important regulatory roles in the
development of various cancers. However, biological functions and the underlying …

Abstract N6-Methyladenosine (m6A) modification has been implicated in the progression of
several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one …

Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …

Abstract Background Non-coding RNAs (ncRNAs) have been shown to regulate gene
expression involved in tumor progression of multiple malignancies. Our previous studies …

Aim: To develop a web tool for survival analysis based on CpG methylation patterns.
Materials & methods: We utilized methylome data from 'The Cancer Genome Atlas' and used …

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

Chemotherapy is currently the main treatment for unresectable or advanced postoperative
gastric cancers. However, its efficacy is negatively affected by the occurrence of …