Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Develo** small molecules that modulate protein …
opportunities for therapeutic intervention. Develo** small molecules that modulate protein …
Protein–protein interactions as drug targets
M Skwarczynska, C Ottmann - Future medicinal chemistry, 2015 - Taylor & Francis
Modulation of protein–protein interactions (PPIs) is becoming increasingly important in drug
discovery and chemical biology. While a few years ago this 'target class' was deemed to be …
discovery and chemical biology. While a few years ago this 'target class' was deemed to be …
Steric-switched defluorofunctionalization selectivity: controlled synthesis of monofluoroalkene-masked medium-sized heterocyclic lactams and lactones
H Zeng, H Li, H Jiang, C Zhu - Science China Chemistry, 2022 - Springer
The steric-switched ipso-defluoroamination-triggered and ipso-defluorooxylation-triggered
cyclization of (trifluoromethyl) alkenes with amino alcohols and diamines are achieved …
cyclization of (trifluoromethyl) alkenes with amino alcohols and diamines are achieved …
Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction: design and mechanism of action
T Zimmerman, FJ Blanco - Current pharmaceutical design, 2008 - ingentaconnect.com
Leukocyte-function associated antigen-1 (LFA-1) is an αLβ2 chain integrin expressed on the
surface of endothelial cells that modulates the behavior of leukocytes by mediating their …
surface of endothelial cells that modulates the behavior of leukocytes by mediating their …
Synthesis of 1, 4-diazepinone derivatives via a domino aza-Michael/SN 2 cyclization of 1-azadienes with α-halogenoacetamides
C Yuan, H Zhang, M Yuan, L **e, X Cao - Organic & Biomolecular …, 2020 - pubs.rsc.org
A novel cyclization of α-halogenoacetamides with 1-azadienes has been developed for the
efficient preparation of monocyclic 1, 4-diazepinones in one step under transition metal-free …
efficient preparation of monocyclic 1, 4-diazepinones in one step under transition metal-free …
Phosphine-triggered tandem annulation between Morita–Baylis–Hillman carbonates and dinucleophiles: Facile syntheses of oxazepanes, thiazepanes, and …
R Zhou, J Wang, C Duan, Z He - Organic letters, 2012 - ACS Publications
A new phosphine-triggered tandem [3+ 4] annulation reaction between Morita–Baylis–
Hillman carbonates and 1, 4-diheteroatom dinucleophiles has been developed, which …
Hillman carbonates and 1, 4-diheteroatom dinucleophiles has been developed, which …
LFA-1 as a key regulator of immune function: approaches toward the development of LFA-1-based therapeutics
PA Giblin, RM Lemieux - Current pharmaceutical design, 2006 - ingentaconnect.com
Over the past decade, Lymphocyte Function-Associated Antigen-1 (LFA-1, αLβ2,
CD11a/CD18) has emerged as an attractive therapeutic target for the treatment of multiple …
CD11a/CD18) has emerged as an attractive therapeutic target for the treatment of multiple …
Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 …
G Weitz-Schmidt, K Welzenbach, J Dawson… - Journal of Biological …, 2004 - ASBMB
The integrin lymphocyte function-associated antigen-1 (LFA-1)(α L β 2; CD11a/CD18) plays
an important role in leukocyte migration and T cell activation. LFA-1 is inhibited by the …
an important role in leukocyte migration and T cell activation. LFA-1 is inhibited by the …
Convenient preparation of chiral phase-transfer catalysts with conformationally fixed biphenyl core for catalytic asymmetric synthesis of α-alkyl-and α, α-dialkyl-α …
YG Wang, M Ueda, X Wang, Z Han, K Maruoka - Tetrahedron, 2007 - Elsevier
Chiral phase-transfer catalysts (S)-1a,(S)-1b, and (S)-2 with conformationally fixed biphenyl
cores were conveniently prepared from the known, easily available (S)-6, 6 …
cores were conveniently prepared from the known, easily available (S)-6, 6 …
Chlorotrimethylsilane-mediated Friedländer Synthesis of polysubstituted quinolines
Thieme E-Journals - Synthesis / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNTHESIS Full-text search Full-text search Author …
Service Library Service Help Contact Portal SYNTHESIS Full-text search Full-text search Author …