Antioxidant and adaptative response mediated by Nrf2 during physical exercise

N Vargas-Mendoza, Á Morales-González… - Antioxidants, 2019 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a powerful nuclear transcription factor that
coordinates an antioxidant cytoprotector system complex stimulated by the increase in …

Circadian synchrony: sleep, nutrition, and physical activity

KL Healy, AR Morris, AC Liu - Frontiers in network physiology, 2021 - frontiersin.org
The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …

Looking beyond PGC-1α: emerging regulators of exercise-induced skeletal muscle mitochondrial biogenesis and their activation by dietary compounds

H Islam, DA Hood, BJ Gurd - Applied Physiology, Nutrition, and …, 2020 - cdnsciencepub.com
Despite its widespread acceptance as the “master regulator” of mitochondrial biogenesis (ie,
the expansion of the mitochondrial reticulum), peroxisome proliferator-activated receptor …

The role of Nrf2 in skeletal muscle on exercise capacity

Y Kitaoka - Antioxidants, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 Nfe2l2 (Nrf2) is believed to play a crucial role in
protecting cells against oxidative stress. In addition to its primary function of maintaining …

Combined effects of green tea supplementation and eccentric exercise on nuclear factor erythroid 2-related factor 2 activity

J Thorley, C Thomas, N Thon, H Nuttall… - European Journal of …, 2024 - Springer
Purpose This study investigated whether combining eccentric exercise and green tea
supplementation synergistically increased nuclear factor erythroid 2-related factor 2 (NRF2) …

[HTML][HTML] Phytochemicals and modulation of exercise-induced oxidative stress: A novel overview of antioxidants

N Vargas-Mendoza, Á Morales-González… - American journal of …, 2022 - ncbi.nlm.nih.gov
The practice of physical exercise induces a series of physiological changes in the body at
different levels, either acutely or chronically. During exercise, the increase in oxygen …

The impact of acute and chronic exercise on Nrf2 expression in relation to markers of mitochondrial biogenesis in human skeletal muscle

H Islam, JT Bonafiglia, PC Turnbull… - European journal of …, 2020 - Springer
Purpose To examine the relationship between changes in nuclear factor erythroid 2-related
factor 2 (Nrf2) expression and markers of mitochondrial biogenesis in acutely and …

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and exercise

AR Mallard, JG Spathis, JS Coombes - Free Radical Biology and Medicine, 2020 - Elsevier
Chronic metabolic health diseases are increasing worldwide placing strain on healthcare
systems and importantly, impacting individuals' quality of life. It is well established that many …

Glyoxalase I is a novel target for the prevention of metabolic derangement

ER Miranda, JM Haus - Pharmacology & Therapeutics, 2023 - Elsevier
Obesity prevalence in the US has nearly tripled since 1975 and a parallel increase in
prevalence of type 2 diabetes (T2D). Obesity promotes a myriad of metabolic derangements …

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans

EL Ostrom, T Traustadóttir - Free Radical Biology and Medicine, 2020 - Elsevier
Nuclear factor erythroid-2-related factor 2 (Nrf2), is an inducible transcription factor that
improves redox balance through stimulating antioxidant gene expression. In older humans …