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LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation
Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …
Beyond T cell exhaustion: TIM-3 regulation of myeloid cells
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …
TIM3 comes of age as an inhibitory receptor
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Tolerance to self-antigens prevents the elimination of cancer by the immune system,. We
used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and …
used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and …
CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
T‐cell exhaustion in HIV infection
The T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming …
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T
cell responses and have proven to be effective targets in the setting of chronic diseases …
cell responses and have proven to be effective targets in the setting of chronic diseases …
Tim‐3 and its role in regulating anti‐tumor immunity
Immunotherapy is being increasingly recognized as a key therapeutic modality to treat
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
TIM-3: An update on immunotherapy
L Zhao, S Cheng, L Fan, B Zhang, S Xu - International …, 2021 - Elsevier
T cell immunoglobulin and mucin domain 3 (TIM-3) was originally found to be expressed on
the surface of Th1 cells, acting as a negative regulator and binding to the ligand galectin-9 to …
the surface of Th1 cells, acting as a negative regulator and binding to the ligand galectin-9 to …
CD8 T cell exhaustion during chronic viral infection and cancer
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …