Steering masked discrete diffusion models via discrete denoising posterior prediction

J Rector-Brooks, M Hasan, Z Peng, Z Quinn… - arxiv preprint arxiv …, 2024 - arxiv.org
Generative modeling of discrete data underlies important applications spanning text-based
agents like ChatGPT to the design of the very building blocks of life in protein sequences …

How discrete and continuous diffusion meet: Comprehensive analysis of discrete diffusion models via a stochastic integral framework

Y Ren, H Chen, GM Rotskoff, L Ying - arxiv preprint arxiv:2410.03601, 2024 - arxiv.org
Discrete diffusion models have gained increasing attention for their ability to model complex
distributions with tractable sampling and inference. However, the error analysis for discrete …

Reliable machine learning models in genomic medicine using conformal prediction

C Papangelou, K Kyriakidis, P Natsiavas, I Chouvarda… - medRxiv, 2024 - medrxiv.org
Machine learning and genomic medicine are the mainstays of research in delivering
personalized healthcare services for disease diagnosis, risk stratification, tailored treatment …

Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension

J Li, T Chen, S Luo, C Cheng, J Guan, R Guo… - arxiv preprint arxiv …, 2024 - arxiv.org
Peptides, short chains of amino acids, interact with target proteins, making them a unique
class of protein-based therapeutics for treating human diseases. Recently, deep generative …

Wasserstein Flow Matching: Generative modeling over families of distributions

D Haviv, AA Pooladian, D Pe'er, B Amos - arxiv preprint arxiv:2411.00698, 2024 - arxiv.org
Generative modeling typically concerns the transport of a single source distribution to a
single target distribution by learning (ie, regressing onto) simple probability flows. However …

Generative Assignment Flows for Representing and Learning Joint Distributions of Discrete Data

B Boll, D Gonzalez-Alvarado, S Petra… - arxiv preprint arxiv …, 2024 - arxiv.org
We introduce a novel generative model for the representation of joint probability distributions
of a possibly large number of discrete random variables. The approach uses measure …

Fast Solvers for Discrete Diffusion Models: Theory and Applications of High-Order Algorithms

Y Ren, H Chen, Y Zhu, W Guo, Y Chen… - arxiv preprint arxiv …, 2025 - arxiv.org
Discrete diffusion models have emerged as a powerful generative modeling framework for
discrete data with successful applications spanning from text generation to image synthesis …