DNA methylation in mammalian development and disease

ZD Smith, S Hetzel, A Meissner - Nature Reviews Genetics, 2024 - nature.com
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Advances in single-cell omics and multiomics for high-resolution molecular profiling

J Lim, C Park, M Kim, H Kim, J Kim… - Experimental & Molecular …, 2024 - nature.com
Single-cell omics technologies have revolutionized molecular profiling by providing high-
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …

Single-cell analysis of chromatin accessibility in the adult mouse brain

S Zu, YE Li, K Wang, EJ Armand, S Mamde, ML Amaral… - Nature, 2023 - nature.com
Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …

Targeting neuronal epigenomes for brain rejuvenation

S Zocher - The EMBO journal, 2024 - embopress.org
Aging is associated with a progressive decline of brain function, and the underlying causes
and possible interventions to prevent this cognitive decline have been the focus of intense …

MYT1L deficiency impairs excitatory neuron trajectory during cortical development

A Yen, S Sarafinovska, X Chen, DD Skinner… - Nature …, 2024 - nature.com
Mutations reducing the function of MYT1L, a neuron-specific transcription factor, are
associated with a syndromic neurodevelopmental disorder. MYT1L is used as a pro-neural …

Challenges and Opportunities in the Clinical Translation of High-Resolution Spatial Transcriptomics

TM Pentimalli, N Karaiskos… - Annual Review of …, 2024 - annualreviews.org
Pathology has always been fueled by technological advances. Histology powered the study
of tissue architecture at single-cell resolution and remains a cornerstone of clinical …

Cellular atlases of the entire mouse brain

MA Tosches, HJ Lee - 2023 - nature.com
Cellular atlases of the entire mouse brain Skip to main content Thank you for visiting nature.com.
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