Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …

Lung cancer is the second most frequently diagnosed cancer and the leading cause of
cancer-related mortality worldwide. Tumour ecosystems feature diverse immune cell types …

Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in
the tumor microenvironment, leading to immunosuppressive features. Here, we employed …

Cancer is a progressive disease that can develop and evolve over decades, with
inflammation playing a central role at each of its stages, from tumor initiation to metastasis. In …

Macrophages are vital tissue components involved in organogenesis, maintaining
homeostasis, and responses to disease. Mouse models have significantly improved our …

Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …

Background IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the
posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is …

Organogenesis is a complex process that relies on a dynamic interplay between extrinsic
factors originating from the microenvironment and tissue-specific intrinsic factors. For …

Cells that lack p53 signaling frequently occur in ulcerative colitis (UC) and are considered
early drivers in UC-associated colorectal cancer (CRC). Epithelial injury during colitis is …