Role of mitochondria in pathogenesis and therapy of renal fibrosis

X Zhao, Y Li, J Yu, H Teng, S Wu, Y Wang, H Zhou, F Li - Metabolism, 2024 - Elsevier
Renal fibrosis, specifically tubulointerstitial fibrosis, represents the predominant pathological
consequence observed in the context of progressive chronic kidney conditions. The …

Targeted Mitochondrial Function for Cardiac Fibrosis: an Epigenetic Perspective

P Liu, ZY Liu, S Mao, XY Shen, ZY Liu, LC Lin… - Free Radical Biology …, 2025 - Elsevier
Mitochondria, commonly referred to as “energy factories” of cells, play a crucial role in the
function and survival of cardiomyocytes. However, as research on cardiac fibrosis has …

[HTML][HTML] Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes

D Wang, X Yu, K Gao, F Li, X Li, H Pu, P Zhang, S Guo… - Redox Biology, 2024 - Elsevier
Ongoing inflammation in the heart is positively correlated with adverse remodeling,
characterized by elevated levels of cytokines that stimulate activation of cardiac fibroblasts. It …

Mitochondrial dysfunction and metabolic reprogramming induce macrophage pro-inflammatory phenotype switch and atherosclerosis progression in aging

AE Vendrov, A Lozhkin, T Hayami, J Levin… - Frontiers in …, 2024 - frontiersin.org
Introduction Aging increases the risk of atherosclerotic vascular disease and its
complications. Macrophages are pivotal in the pathogenesis of vascular aging, driving …

Macrophage OTUD1‐CARD9 axis drives isoproterenol‐induced inflammatory heart remodelling

J Qian, Q Wang, J Xu, S Liang, Q Zheng… - Clinical and …, 2024 - Wiley Online Library
Background Chronic inflammation contributes to the progression of isoproterenol (ISO)‐
induced heart failure (HF). Caspase‐associated recruitment domain (CARD) families are …

Nutritional Advantages of Walnut (Juglans regia L.) for Cardiovascular Diseases: A Comprehensive Review

M Rashki, M Ghasemzadeh Rahbardar… - Food Science & …, 2025 - Wiley Online Library
Cardiovascular diseases (CVDs) remain one of the leading causes of morbidity and
mortality worldwide. In recent years, the potential role of dietary interventions in preventing …

Interplay between energy metabolism and NADPH oxidase-mediated pathophysiology in cardiovascular diseases

H Jie, J Zhang, S Wu, L Yu, S Li, B Dong… - Frontiers in …, 2025 - frontiersin.org
Sustained production of reactive oxygen species (ROS) and an imbalance in the antioxidant
system have been implicated in the development of cardiovascular diseases (CVD) …

Macrophages in cardiovascular fibrosis: novel subpopulations, molecular mechanisms, and therapeutic targets

R Li, X Li, X Zhang, J Yu, Y Li, S Ran, S Wang… - Canadian Journal of …, 2024 - Elsevier
Cardiovascular fibrosis is a common pathological process that contributes to the
development and progression of various cardiovascular diseases. Despite being widely …

At the heart of inflammation: Unravelling cardiac resident macrophage biology

Y Liao, L Zhu - Journal of Cellular and Molecular Medicine, 2024 - Wiley Online Library
Cardiovascular disease remains one of the leading causes of death globally. Recent
advancements in sequencing technologies have led to the identification of a unique …

Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify …

S Zhang, Y Huang, C Han, F Wang, M Chen… - International …, 2025 - Elsevier
Background Sodium/glucose co-transporter 2 (SGLT2) inhibitors have transformed heart
failure (HF) treatment, offering sympatholytic effects whose mechanisms are not fully …