The collagen suprafamily: from biosynthesis to advanced biomaterial development
Collagen is the oldest and most abundant extracellular matrix protein that has found many
applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview …
applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview …
3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …
Cell-derived extracellular matrix for tissue engineering and regenerative medicine
Cell-derived extracellular matrices (CD-ECMs) captured increasing attention since the first
studies in the 1980s. The biological resemblance of CD-ECMs to their in vivo counterparts …
studies in the 1980s. The biological resemblance of CD-ECMs to their in vivo counterparts …
[HTML][HTML] It is time to crowd your cell culture media–physicochemical considerations with biological consequences
D Tsiapalis, DI Zeugolis - Biomaterials, 2021 - Elsevier
In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …
Bioactive decellularized extracellular matrix derived from 3D stem cell spheroids under macromolecular crowding serves as a scaffold for tissue engineering
CE Chiang, YQ Fang, CT Ho… - Advanced …, 2021 - Wiley Online Library
Scaffolds for tissue engineering aim to mimic the native extracellular matrix (ECM) that
provides physical support and biochemical signals to modulate multiple cell behaviors …
provides physical support and biochemical signals to modulate multiple cell behaviors …
An experimental toolbox for characterization of mammalian collagen type I in biological specimens
Collagen type I is the most abundant extracellular matrix protein, and collagen type I
supramolecular assemblies (eg, tissue grafts, biomaterials and cell-assembled systems) are …
supramolecular assemblies (eg, tissue grafts, biomaterials and cell-assembled systems) are …
Searching for molecular hypoxia sensors among oxygen-dependent enzymes
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic
organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen …
organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen …
Cell‐derived extracellular matrix‐rich biomimetic substrate supports podocyte proliferation, differentiation, and maintenance of native phenotype
Current technologies and available scaffold materials do not support long‐term cell viability,
differentiation, and maintenance of podocytes, the ultra‐specialized kidney resident cells …
differentiation, and maintenance of podocytes, the ultra‐specialized kidney resident cells …
Polydispersity and negative charge are key modulators of extracellular matrix deposition under macromolecular crowding conditions
Macromolecular crowding is a biophysical phenomenon that stems from the volume
excluded by macromolecules, as they undergo steric repulsion and electrostatic interactions …
excluded by macromolecules, as they undergo steric repulsion and electrostatic interactions …