Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and
functions mainly involve in regulating energy response-related physiological processes …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …

Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …

Summary Exhausted CD8 T (T ex) cells in chronic viral infection and cancer have sustained
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …

Small cell lung cancer (SCLC) is widely considered to be a tumor of pulmonary
neuroendocrine cells; however, a variant form of this disease has been described that lacks …

The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in
inflammation and host defense; however, the underlying molecular mechanism remains …

Summary Interferon-gamma (IFN-γ) has pleiotropic effects on cancer immune checkpoint
blockade (ICB), including roles in ICB resistance. We analyzed gene expression in ICB …

The aberrant expression of squamous lineage markers in pancreatic ductal
adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the …

Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has
been driven by therapies that have limited applications beyond MM/PC neoplasias and do …