Dilated cardiomyopathy: genetic determinants and mechanisms
Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …
Organs-on-a-chip: a fast track for engineered human tissues in drug development
Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …
modeling of human physiology and disease. The technology has emerged from converging …
Present Status of Brugada Syndrome: JACC State-of-the-Art Review
The Brugada syndrome is an inherited disorder associated with risk of ventricular fibrillation
and sudden cardiac death in a structurally normal heart. Diagnosis is based on a …
and sudden cardiac death in a structurally normal heart. Diagnosis is based on a …
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
M Abulaiti, Y Yalikun, K Murata, A Sato, MM Sami… - Scientific reports, 2020 - nature.com
Human iPS cell (iPSC)-derived cardiomyocytes (CMs) hold promise for drug discovery for
heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the …
heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American Heart Association
K Musunuru, F Sheikh, RM Gupta… - Circulation: Genomic …, 2018 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …
physiology and disease at the cellular level. They also have the potential to be leveraged in …
Genome editing in induced pluripotent stem cells using CRISPR/Cas9
R Ben Jehuda, Y Shemer, O Binah - Stem Cell Reviews and Reports, 2018 - Springer
The development of the reprogramming technology led to generation of induced Pluripotent
Stem Cells (iPSC) from a variety of somatic cells. Ever since, fast growing knowledge of …
Stem Cells (iPSC) from a variety of somatic cells. Ever since, fast growing knowledge of …
Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity
Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …
market. Several chemotherapeutic compounds have been noted for their propensities to …
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients
Aims Diastolic dysfunction (DD) is common among hypertrophic cardiomyopathy (HCM)
patients, causing major morbidity and mortality. However, its cellular mechanisms are not …
patients, causing major morbidity and mortality. However, its cellular mechanisms are not …
Determining the pathogenicity of a genomic variant of uncertain significance using CRISPR/Cas9 and human-induced pluripotent stem cells
Background: The progression toward low-cost and rapid next-generation sequencing has
uncovered a multitude of variants of uncertain significance (VUS) in both patients and …
uncovered a multitude of variants of uncertain significance (VUS) in both patients and …