Viruses have been responsible for many epidemics and pandemics that have impacted
human life globally. The COVID-19 pandemic highlighted both our vulnerability to viral …

Broadly neutralizing antibodies (bNAbs) targeting the apex of the HIV-1-envelope (Env)
trimer comprise the most potent category of HIV-1 bNAbs and have emerged as promising …

With over 270 unique occurrences in the human genome, peptide-recognizing PDZ domains
play a central role in modulating polarization, signaling, and trafficking pathways. Mutations …

Motivation Engineering high-affinity binders targeting specific antigenic determinants
remains a challenging and often daunting task, requiring extensive experimental screening …

D-peptides, the mirror image of canonical L-peptides, offer numerous biological advantages
that make them effective therapeutics. This article details how to use DexDesign, the newest …

In the rapidly evolving field of biotherapeutics, the intersection of computational science and
protein engineering has revolutionized the approach to drug discovery and development …

Potent and broadly neutralizing antibodies (NAbs) are important for clearance of RNA virus
infections. However, NAbs generated in response to RNA viruses exhibit diverse profiles of …

Accurate binding affinity prediction is crucial to structure-based drug design. Recent work
used computational topology to obtain an effective representation of protein-ligand …

New Computational Methods to Predict Cancer Resistance Mutations and Design D-Peptide
Therapeutics Page 1 i v New Computational Methods to Predict Cancer Resistance …