Advances in nanomaterial-based targeted drug delivery systems

X Cheng, Q **e, Y Sun - Frontiers in bioengineering and …, 2023 - frontiersin.org
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety
and therapeutic efficacy of encapsulated drugs due to their unique physicochemical and …

Strategies to improve the EPR effect: a mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Y Di, R Deng, Z Liu, Y Mao, Y Gao, Q Zhao, S Wang - Biomaterials, 2023 - Elsevier
Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor
growth, metastasis, death and other biological processes. ROS-based nanodynamic …

Recent advances in dual-and multi-responsive nanomedicines for precision cancer therapy

Y Zhang, J Li, K Pu - Biomaterials, 2022 - Elsevier
Nanomedicines have been regarded as a potential approach in the field of cancer treatment
due to their unique advantages. Although improved therapeutic efficacy can be achieved …

Reactive oxygen species-sensitive polymeric nanocarriers for synergistic cancer therapy

Z Cao, D Li, J Wang, X Yang - Acta biomaterialia, 2021 - Elsevier
Reactive oxygen species (ROS)-responsive nanocarriers have aroused widespread interest
in recent years. On the one hand, a high ROS level has been detected in many types of …

Current limitations and recent progress in nanomedicine for clinically available photodynamic therapy

J Park, YK Lee, IK Park, SR Hwang - Biomedicines, 2021 - mdpi.com
Photodynamic therapy (PDT) using oxygen, light, and photosensitizers has been receiving
great attention, because it has potential for making up for the weakness of the existing …

pH/ROS dual-responsive supramolecular polypeptide prodrug nanomedicine based on host-guest recognition for cancer therapy

Y Ding, C Wang, Y Ma, L Zhu, B Lu, Y Wang, J Wang… - Acta Biomaterialia, 2022 - Elsevier
Supramolecular nanomedicine assembly combined with polypeptide prodrug could become
a powerful strategy to minimize drug leakage in blood circulation and trigger sufficient drug …

Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species

RS Chasara, TO Ajayi, DM Leshilo, MS Poka, BA Witika - Heliyon, 2023 - cell.com
The cellular milieu in which malignant growths or cancer stem cells reside is known as the
tumour microenvironment (TME). It is the consequence of the interactivity amongst malignant …

Overcoming challenges in cancer treatment: nano‐enabled photodynamic therapy as a viable solution

SS Rajan, R Chandran… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Cancer presents a formidable challenge, necessitating innovative therapies that maximize
effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as a …

Hypoxia‐responsive tetrameric supramolecular polypeptide nanoprodrugs for combination therapy

Y Ding, W Yu, R Shen, X Zheng… - Advanced …, 2024 - Wiley Online Library
Despite the intense progress of photodynamic and chemotherapy, however, they cannot
prevent solid tumor invasion, metastasis, and relapse, along with inferior efficacy and severe …