The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of
macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Aging is the progressive accumulation of damage to an organism over time leading to
disease and death. Aging research has been very intensive in the last years aiming at …

We review the cellular and physiological mechanisms responsible for the regulation of blood
flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the …

Hesperidin and hesperetin are polyphenols that can be found predominantly in citrus fruits.
They possess a variety of pharmacological properties such as neuroprotective and …

The role of advanced glycation end products (AGEs) in promoting and/or exacerbating
metabolic dysregulation is being increasingly recognized. AGEs are formed when reducing …

Significance: The mitochondrial matrix contains much of the machinery at the heart of
metabolism. This compartment is also exposed to a high and continual flux of superoxide …

Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on
exposure to high glucose concentrations, inflammation, cell aging and senescence. It is …