Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects~
10% of the 193 million cannabis users worldwide. The individual and public health burdens …

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address
limitations of traditional mental disorder diagnoses. These include arbitrary boundaries …

Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …

Cannabis use is a heritable trait that has been associated with adverse mental health
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …

Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …

In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

Objective This review of the scientific literature examines the potential adult sequelae of
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …

Aims Cannabis and tobacco use and misuse frequently co‐occur. This review examines the
epidemiological evidence supporting the life‐time co‐occurrence of cannabis and tobacco …

Abstract The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis)
Consortium was set up to analyze brain measures and genotypes from multiple sites across …

There is a growing body of evidence pointing to the co-occurrence of cannabis use and
depression. There is also some evidence that the use of cannabis may lead to the onset of …