Over the past several decades, an overwhelming body of research has greatly expanded
our understanding of the mechanisms underlying excitotoxicity in brain ischemia as well as …

Calcium is a highly positively charged ionic species. It regulates all cell types' functions and
is an important second messenger that controls and triggers several mechanisms, including …

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …

The remodelling of neuronal ionic homeostasis by altered channels and transporters is a
critical feature of the Alzheimer's disease (AD) pathogenesis. Different reports converge on …

Abstract Mammalian Na+/Ca2+ exchangers, NCX1 and NCX3, generate splice variants,
whereas NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12) …

Abstract Intracellular [Na+] i and [Ca 2+] i imbalance significantly contribute to neuro-axonal
dysfunctions and maladaptive myelin repair or remyelination failure in chronic inflammatory …

α-Latrotoxin (αLTX) causes exhaustive release of neurotransmitters from nerve terminals in
the absence of extracellular Ca2+ (Ca2+ e). To investigate the mechanisms underlying this …

Abstract NCX1, NCX2, and NCX3 gene isoforms and their splice variants are
characteristically expressed in different regions of the brain. The tissue-specific splice …