Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …

Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of
mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Mutations in several general pre-mRNA splicing factors have been linked to myelodysplastic
syndromes (MDSs) and solid tumors. These mutations have generally been assumed to …

Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of
hematopoietic stem cells (HSCs). The current standard of care for patients with MDS is …

Examples of associations between human disease and defects in pre–messenger RNA
splicing/alternative splicing are accumulating. Although many alterations are caused by …

Deregulation of precursor mRNA splicing is associated with many illnesses and has been
linked to age‐related chronic diseases. Here we review recent progress documenting how …

In mammals, telomere protection is mediated by the essential protein TRF2, which binds
chromosome ends and ensures genome integrity,. TRF2 depletion results in end-to-end …

Amplification of 1q21 occurs in approximately 30% of de novo and 70% of relapsed multiple
myeloma (MM) and is correlated with disease progression and drug resistance. Here, we …