Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by
proalgesic agents such as nerve growth factor (NGF). The currently accepted model is that …

Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …

Smooth muscle cells are ultimately responsible for determining vascular luminal diameter
and blood flow. Dynamic changes in intracellular calcium are a critical mechanism …

Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …

Rationale: L-Type (Cav1. 2) Ca2+ channels are critical regulators of muscle and neural
function. Although Cav1. 2 channel activity varies regionally, little is known about the …

In the heart, reliable activation of Ca2+ release from the sarcoplasmic reticulum during the
plateau of the ventricular action potential requires synchronous opening of multiple CaV1. 2 …

Myogenic, or pressure-induced, vasoconstriction is critical for local blood flow
autoregulation. Underlying this vascular smooth muscle (VSM) response are events …

The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …