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Genetics and pathogenesis of Parkinson's syndrome
Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …
Networking brainstem and basal ganglia circuits for movement
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …
throughout the nervous system. The brainstem and basal ganglia are key for processing …
Spontaneous behaviour is structured by reinforcement without explicit reward
Spontaneous animal behaviour is built from action modules that are concatenated by the
brain into sequences,. However, the neural mechanisms that guide the composition of …
brain into sequences,. However, the neural mechanisms that guide the composition of …
Disruption of mitochondrial complex I induces progressive parkinsonism
Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the
substantia nigra is a hallmark of Parkinson's disease. Yet, whether this change contributes to …
substantia nigra is a hallmark of Parkinson's disease. Yet, whether this change contributes to …
Piezoelectric nanomaterials activated by ultrasound: the pathway from discovery to future clinical adoption
Electrical stimulation has shown great promise in biomedical applications, such as
regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical …
regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical …
Computational psychiatry: from synapses to sentience
This review considers computational psychiatry from a particular viewpoint: namely, a
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …
commitment to explaining psychopathology in terms of pathophysiology. It rests on the …
Circuits and functions of the lateral habenula in health and in disease
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …
owing to new discoveries relating to its critical role in regulating negatively motivated …
Spatial and temporal scales of dopamine transmission
Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …
Striatal circuits for reward learning and decision-making
The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …
those actions. Decades of experimental and theoretical work have led to several influential …
Dopamine: functions, signaling, and association with neurological diseases
The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …