Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
Cellular functions of cGAS-STING signaling
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
New frontiers in the cGAS-STING intracellular DNA-sensing pathway
Summary The cGAS-STING intracellular DNA-sensing pathway has emerged as a key
element of innate antiviral immunity and a promising therapeutic target. The existence of an …
element of innate antiviral immunity and a promising therapeutic target. The existence of an …
[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
[HTML][HTML] Resurrection of endogenous retroviruses during aging reinforces senescence
Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …
limiting the development of strategies to ameliorate age-related pathologies by preventing …
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
[HTML][HTML] A stem cell aging framework, from mechanisms to interventions
Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …
Decades of scientific research have uncovered processes of stem cell decline in tissue and …
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
[HTML][HTML] S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis
F Liu, L Yuan, L Li, J Yang, J Liu, Y Chen… - Pharmacological …, 2023 - Elsevier
Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …