Non‐equilibrium chemical systems underpin multiple domains of contemporary interest,
including supramolecular chemistry, molecular machines, systems chemistry, prebiotic …

The origin of nucleotides is a major question in origins-of-life research. Given the central
importance of RNA in biology and the influential RNA World hypothesis, a great deal of this …

Chemically driven reaction cycles are prevalent in nature; yet, artificial examples are still
rare and often lack robustness or versatility. In this study, we introduce acylphosphate steady …

We propose a model for the replication of primordial protocell genomes that builds upon
recent advances in the nonenzymatic copying of RNA. We suggest that the original …

Recent advances in prebiotic chemistry are beginning to outline plausible pathways for the
synthesis of the canonical ribonucleotides and their assembly into oligoribonucleotides …

The abiotic synthesis of ribonucleotides is thought to have been an essential step toward the
emergence of the RNA world. However, it is likely that the prebiotic synthesis of …

Recent demonstrations of RNA–DNA chimeras (RDNA) enabling RNA and DNA replication,
coupled with prebiotic co‐synthesis of deoxyribo‐and ribo‐nucleotides, have resurrected the …

Life emerging in an RNA world is expected to propagate RNA as hereditary information,
requiring some form of primitive replication without enzymes. Non-enzymatic template …

Aminoacylated tRNAs are the substrates for ribosomal protein synthesis in all branches of
life, implying an ancient origin for aminoacylation chemistry. In the 1970s, Orgel and …

The aqueous self‐assembly of amphiphiles into aggregates such as micelles and vesicles
has been widely investigated over the past decades with applications ranging from materials …