Major depressive disorder
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …
Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
Digital era 4.0: The contribution to education and student psychology
This study aims to explain the challenges of teachers in the digital era 4.0 and readiness to
face these challenges. Through literature review. The author explains that there are several …
face these challenges. Through literature review. The author explains that there are several …
Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …
notably depression. However, the comparative performance of different formulations of …
[HTML][HTML] Treatment resistance in psychiatry: state of the art and new directions
OD Howes, ME Thase, T Pillinger - Molecular psychiatry, 2022 - nature.com
Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …
associated with increased healthcare burden and costs up to ten-fold higher relative to …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
Depression in the primary care setting
Key Clinical Points Depression in the Primary Care Setting Screening for depression and
suicidal thinking and behavior is important in the primary care setting. Distinguishing …
suicidal thinking and behavior is important in the primary care setting. Distinguishing …
Efficacy and safety of fixed-dose esketamine nasal spray combined with a new oral antidepressant in treatment-resistant depression: results of a randomized, double …
M Fedgchin, M Trivedi, EJ Daly… - International Journal …, 2019 - academic.oup.com
Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant …
treatment with multiple antidepressants and are considered to have treatment-resistant …
Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial
Objective To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and
at six weeks, overall and according to diagnostic group. Design Prospective, double blind …
at six weeks, overall and according to diagnostic group. Design Prospective, double blind …