Introduction: Adverse childhood experiences (ACE) such as sexual and physical abuse or
neglect are frequent in childhood and constitute a massive stressor with long-lasting …

Maltreatment-related childhood adversity is the leading preventable risk factor for mental
illness and substance abuse. Although the association between maltreatment and …

Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for develo** …

Background Adverse psychosocial exposures in early life, namely experiences such as child
maltreatment, caregiver stress or depression, and domestic or community violence, have …

Childhood adversity is a major risk factor for multiple forms of psychopathology, and recent
efforts have focused on understanding the underlying psychological mechanisms. One …

Background Childhood maltreatment is the most important preventable cause of
psychopathology accounting for about 45% of the population attributable risk for childhood …

Children who have experienced environmental adversity—such as abuse, neglect, or
poverty—are more likely to develop physical and mental health problems, perform poorly at …

Despite long-standing interest in the influence of adverse early experiences on mental
health, systematic scientific inquiry into childhood adversity and developmental outcomes …

Children exposed to various forms of adversity early in life are at increased risk for a broad
range of developmental difficulties, affecting both cognitive and emotional adjustment. We …

Children who experience chronic stressors are vulnerable to emotional and physical health
problems across the lifespan. This phenomenon raises questions for scientists and …