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CyTOF® for the Masses
Mass cytometry has revolutionized immunophenoty**, particularly in exploratory settings
where simultaneous breadth and depth of characterization of immune populations is needed …
where simultaneous breadth and depth of characterization of immune populations is needed …
Mass cytometry: single cells, many features
Technology development in biological research often aims to either increase the number of
cellular features that can be surveyed simultaneously or enhance the resolution at which …
cellular features that can be surveyed simultaneously or enhance the resolution at which …
[HTML][HTML] Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
CD8+ T cell responses are critical for anti-tumor immunity. While extensively profiled in the
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …
Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy
Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen
receptor (CAR) T cell therapies targeting CD19 experience disease progression, and …
receptor (CAR) T cell therapies targeting CD19 experience disease progression, and …
[HTML][HTML] Functional characterization of the dural sinuses as a neuroimmune interface
Despite the established dogma of central nervous system (CNS) immune privilege,
neuroimmune interactions play an active role in diverse neurological disorders. However …
neuroimmune interactions play an active role in diverse neurological disorders. However …
[HTML][HTML] Map** systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)
Initially, children were thought to be spared from disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel …
syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel …
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity
C Hutton, F Heider, A Blanco-Gomez, A Banyard… - Cancer cell, 2021 - cell.com
Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass …
characterization of their heterocellular relationships remains incomplete. Using mass …
[HTML][HTML] Single-cell map** of human brain cancer reveals tumor-specific instruction of tissue-invading leukocytes
E Friebel, K Kapolou, S Unger, NG Núñez, S Utz… - Cell, 2020 - cell.com
Brain malignancies can either originate from within the CNS (gliomas) or invade from other
locations in the body (metastases). A highly immunosuppressive tumor microenvironment …
locations in the body (metastases). A highly immunosuppressive tumor microenvironment …
Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy
B-cell maturation antigen (BCMA) is a prominent tumor-associated target for chimeric
antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case …
antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case …
[HTML][HTML] Spatial CRISPR genomics identifies regulators of the tumor microenvironment
While CRISPR screens are hel** uncover genes regulating many cell-intrinsic processes,
existing approaches are suboptimal for identifying extracellular gene functions, particularly …
existing approaches are suboptimal for identifying extracellular gene functions, particularly …