A long-standing challenge in synthetic chemistry is the direct, selective functionalization of
alkyl, alkenyl, and aryl CH bonds. Much research has been devoted to the selective …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Covering the fundamentals of heterocyclic reactivity and synthesis, this book teaches the
subject in a way that is understandable to graduate students. Recognizing the level at which …

Amines are present in a large majority of drugs and drug candidates. Consequently, the
asymmetric synthesis of amine containing compounds represents an extremely important …

1.1. General Considerations Palladium catalysis is one of the most important synthetic tools
in modern organic synthesis. A particularly attractive synthetic feature of palladium catalysis …

In a previous and recent report, 1 we have highlighted in the introductory section the
transition-metal catalysed carbone carbon bond formation as a fundamental reaction in …

Rhodium-catalyzed asymmetric arylation (RCAA) reactions provide one of the most
straightforward and powerful ways to introduce aryl fragments in an enantioselective …

Monocoordinated palladium catalysts derived from sterically hindered, electron‐rich
phosphines or N‐heterocyclic carbenes have revolutionized the Suzuki–Miyaura coupling …

Pd-catalyzed cross-coupling reactions can be considered nowadays to be the most reliable
methodology for the formation of C (sp2) ÀC (sp2) bonds.[1] These types of reactions find …

The first example of Ir-catalyzed asymmetric substitution reaction with vinyl trifluoroborates is
described. The direct reaction between branched, racemic allylic alcohols and potassium …