p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents
X Sui, N Kong, LI Ye, W Han, J Zhou, Q Zhang, C He… - Cancer letters, 2014 - Elsevier
Abstract The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …
Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
[HTML][HTML] Mechanisms of resistance in castration-resistant prostate cancer (CRPC)
Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …
cancer remains high. Approximately 20% of men present with advanced or metastatic …
Stress relief techniques: p38 MAPK determines the balance of cell cycle and apoptosis pathways
RH Whitaker, JG Cook - Biomolecules, 2021 - mdpi.com
Protein signaling networks are formed from diverse and inter-connected cell signaling
pathways converging into webs of function and regulation. These signaling pathways both …
pathways converging into webs of function and regulation. These signaling pathways both …
Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
Docetaxel (DTX) is a chemotherapeutic agent used in the treatment of various malignancies
but is often associated with central and peripheral neurotoxicity. The aim of this study was to …
but is often associated with central and peripheral neurotoxicity. The aim of this study was to …
Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes
Enzymes of the cytochrome P450 (CYP) subfamily 3A and 2C play a major role in the
metabolism of taxane anticancer agents. While their function in hepatic metabolism of …
metabolism of taxane anticancer agents. While their function in hepatic metabolism of …
New insight into p-glycoprotein as a drug target
A Breier, L Gibalova, M Seres… - Anti-Cancer Agents in …, 2013 - ingentaconnect.com
Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit
reduced sensitivity to a large group of unrelated drugs with different mechanisms of …
reduced sensitivity to a large group of unrelated drugs with different mechanisms of …
[HTML][HTML] Drug resistance in castration resistant prostate cancer: resistance mechanisms and emerging treatment strategies
CM Armstrong, AC Gao - American journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Several mechanisms facilitate the progression of hormone-sensitive prostate cancer to
castration-resistant prostate cancer (CRPC). At present, the approved chemotherapies for …
castration-resistant prostate cancer (CRPC). At present, the approved chemotherapies for …
Taxane mechanisms of action: potential implications for treatment sequencing in metastatic castration-resistant prostate cancer
JM Fitzpatrick, R de Wit - European urology, 2014 - Elsevier
Context In the past few years, there has been a rapid increase in the number of therapies
available to treat metastatic castration-resistant prostate cancer (mCRPC). Currently …
available to treat metastatic castration-resistant prostate cancer (mCRPC). Currently …
Functional p53 determines docetaxel sensitivity in prostate cancer cells
BACKGROUND Docetaxel is the first line treatment for castration resistant prostate cancer
(CRPC). However, docetaxel resistance rapidly develops. Identifying the critical …
(CRPC). However, docetaxel resistance rapidly develops. Identifying the critical …