[HTML][HTML] Cannabinoids and pain: new insights from old molecules
S Vučković, D Srebro, KS Vujović, Č Vučetić… - Frontiers in …, 2018 - frontiersin.org
Cannabis has been used for medicinal purposes for thousands of years. The prohibition of
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …
An introduction to the endogenous cannabinoid system
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …
important roles in central nervous system development, synaptic plasticity, and the response …
The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
The cannabinoid system and pain
Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
Enzyme inhibitor discovery by activity-based protein profiling
MJ Niphakis, BF Cravatt - Annual review of biochemistry, 2014 - annualreviews.org
Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …
Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites
C Turcotte, F Chouinard, JS Lefebvre… - Journal of Leucocyte …, 2015 - academic.oup.com
Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids
that have been implicated in many physiologic disorders, including obesity, metabolic …
that have been implicated in many physiologic disorders, including obesity, metabolic …
The role of the endocannabinoid system in pain
Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia,
but only in recent decades has the endogenous system responsible for these effects been …
but only in recent decades has the endogenous system responsible for these effects been …
Identification of ABX-1431, a selective inhibitor of monoacylglycerol lipase and clinical candidate for treatment of neurological disorders
JS Cisar, OD Weber, JR Clapper… - Journal of medicinal …, 2018 - ACS Publications
The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous
cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols …
cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols …
[HTML][HTML] Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders
H Deng, W Li - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the
hydrolysis of monoglycerides into glycerol and fatty acids. It links the endocannabinoid and …
hydrolysis of monoglycerides into glycerol and fatty acids. It links the endocannabinoid and …
A cannabinoid CB1 receptor-positive allosteric modulator reduces neuropathic pain in the mouse with no psychoactive effects
BM Ignatowska-Jankowska, GL Baillie… - …, 2015 - nature.com
The CB 1 receptor represents a promising target for the treatment of several disorders
including pain-related disease states. However, therapeutic applications of Δ 9 …
including pain-related disease states. However, therapeutic applications of Δ 9 …