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Cardiac fibrosis
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …
extracellular matrix proteins, is a common pathophysiologic companion of many different …
TGF-β1–a truly transforming growth factor in fibrosis and immunity
Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …
Mesenchymal stem cell perspective: cell biology to clinical progress
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …
Skeletal muscle fibrosis: an overview
Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …
framework structure that holds myofibers and blood capillaries and nerves supplying the …
Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β
The fibrotic encapsulation of implants involves the mechanical activation of myofibroblasts
and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both …
and of pro-fibrotic transforming growth factor beta 1 (TGF-β1). Here, we show that both …
Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging
Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …
Five decades later, are mesenchymal stem cells still relevant?
Mesenchymal stem cells are culture-derived mesodermal progenitors isolatable from all
vascularized tissues. In spite of multiple fundamental, pre-clinical and clinical studies, the …
vascularized tissues. In spite of multiple fundamental, pre-clinical and clinical studies, the …