Closed-loop insulin delivery systems: past, present, and future directions

S Templer - Frontiers in Endocrinology, 2022 - frontiersin.org
Closed-loop (artificial pancreas) systems for automated insulin delivery have been likened
to the holy grail of diabetes management. The first iterations of glucose-responsive insulin …

Artificial pancreas: past, present, future

C Cobelli, E Renard, B Kovatchev - Diabetes, 2011 - diabetesjournals.org
The artificial pancreas (AP), known as closed-loop control of blood glucose in diabetes, is a
system combining a glucose sensor, a control algorithm, and an insulin infusion device. AP …

[PDF][PDF] ISPAD clinical practice consensus guidelines 2018: diabetes technologies

JL Sherr, M Tauschmann, T Battelino, M de Bock… - Pediatr Diabetes, 2018 - bnsde.org
ISPAD Clinical Practice Consensus Guidelines 2018: Diabetes technologies Page 1 ISPAD
CLINICAL PRACTICE CONSENSUS GUIDELINES ISPAD Clinical Practice Consensus …

Closed-loop artificial pancreas systems: engineering the algorithms

FJ Doyle III, LM Huyett, JB Lee, HC Zisser… - Diabetes …, 2014 - diabetesjournals.org
In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical
aspects of artificial pancreas (AP) development are described. In the preceding Bench …

Nocturnal glucose control with an artificial pancreas at a diabetes camp

M Phillip, T Battelino, E Atlas… - … England Journal of …, 2013 - Mass Medical Soc
Background Recent studies have shown that an artificial-pancreas system can improve
glucose control and reduce nocturnal hypoglycemia. However, it is not known whether such …

Closed-loop insulin delivery: from bench to clinical practice

R Hovorka - Nature Reviews Endocrinology, 2011 - nature.com
Automated closed-loop insulin delivery, also referred to as the'artificial pancreas', has been
an important but elusive goal of diabetes treatment for many decades. Research milestones …

Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia

M Breton, A Farret, D Bruttomesso, S Anderson… - Diabetes, 2012 - diabetesjournals.org
Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with
insulin pump (continuous subcutaneous insulin infusion [CSII]), known as artificial pancreas …

Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial

R Hovorka, D Elleri, H Thabit, JM Allen… - Diabetes …, 2014 - diabetesjournals.org
OBJECTIVE To evaluate feasibility, safety, and efficacy of overnight closed-loop insulin
delivery in free-living youth with type 1 diabetes. RESEARCH DESIGN AND METHODS …

Enabling fully automated insulin delivery through meal detection and size estimation using artificial intelligence

C Mosquera-Lopez, LM Wilson, J El Youssef… - NPJ digital …, 2023 - nature.com
We present a robust insulin delivery system that includes automated meal detection and
carbohydrate content estimation using machine learning for meal insulin dosing called …

Individualized model predictive control for the artificial pancreas: In silico evaluation of closed-loop glucose control

M Messori, GP Incremona, C Cobelli… - IEEE Control Systems …, 2018 - ieeexplore.ieee.org
Despite the continuous efforts devoted to AP development in the last decades, an artificial
pancreas (AP) system is not yet available on the market. One of the major issues involves …