Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …
Neuroimaging and machine learning for dementia diagnosis: recent advancements and future prospects
Dementia, a chronic and progressive cognitive declination of brain function caused by
disease or impairment, is becoming more prevalent due to the aging population. A major …
disease or impairment, is becoming more prevalent due to the aging population. A major …
Sex effects on brain structure in de novo Parkinson's disease: a multimodal neuroimaging study
Parkinson's disease varies in severity and age of onset. One source of this variability is sex.
Males are twice as likely as females to develop Parkinson's disease, and tend to have more …
Males are twice as likely as females to develop Parkinson's disease, and tend to have more …
Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioral, and …
Background Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental disorders later in life. The impact of the gestational timing of MIA …
neurodevelopmental disorders later in life. The impact of the gestational timing of MIA …
[HTML][HTML] Brain network architecture constrains age-related cortical thinning
Age-related cortical atrophy, approximated by cortical thickness measurements from
magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its …
magnetic resonance imaging, follows a characteristic pattern over the lifespan. Although its …
Comprehensive analysis of brain volume in REM sleep behavior disorder with mild cognitive impairment
D Rémillard-Pelchat, S Rahayel… - Journal of …, 2022 - content.iospress.com
Background: Rapid-eye-movement sleep behavior disorder (RBD) is a major risk factor for
Parkinson's disease and dementia with Lewy bodies. More than a third of RBD patients have …
Parkinson's disease and dementia with Lewy bodies. More than a third of RBD patients have …
A prodromal brain‐clinical pattern of cognition in Synucleinopathies
Objective Isolated (or idiopathic) rapid eye movement sleep behavior disorder (iRBD) is
associated with dementia with Lewy bodies (DLB) and Parkinson's disease (PD) …
associated with dementia with Lewy bodies (DLB) and Parkinson's disease (PD) …
[HTML][HTML] Analyses of microstructural variation in the human striatum using non-negative matrix factorization
The striatum is a major subcortical connection hub that has been heavily implicated in a
wide array of motor and cognitive functions. Here, we developed a normative multimodal …
wide array of motor and cognitive functions. Here, we developed a normative multimodal …
[HTML][HTML] Regional changes of brain structure during progression of idiopathic Parkinson's disease–A longitudinal study using deformation based morphometry
P Pieperhoff, M Südmeyer, L Dinkelbach, CJ Hartmann… - Cortex, 2022 - Elsevier
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum
of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD …
of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD …
Contrastive machine learning reveals Parkinson's disease specific features associated with disease severity and progression
L Zheng, C Zhou, C Mao, C **e, J You… - Communications …, 2024 - nature.com
Parkinson's disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely
due to diverse neuroanatomical alterations. This study employs a contrastive deep learning …
due to diverse neuroanatomical alterations. This study employs a contrastive deep learning …