Exploring new perspectives in immunology

R Medzhitov, A Iwasaki - Cell, 2024 - cell.com
Several conceptual pillars form the foundation of modern immunology, including the clonal
selection theory, antigen receptor diversity, immune memory, and innate control of adaptive …

SARS-CoV-2 correlates of protection from infection against variants of concern

K Sun, JN Bhiman, S Tempia, J Kleynhans… - Nature Medicine, 2024 - nature.com
Serum neutralizing antibodies (nAbs) induced by vaccination have been linked to protection
against symptomatic and severe coronavirus disease 2019. However, much less is known …

Progress and challenges in the clinical evaluation of immune responses to respiratory mucosal vaccines

X Zhang, J Zhang, S Chen, Q He, Y Bai… - Expert Review of …, 2024 - Taylor & Francis
Introduction Following the coronavirus disease pandemic, respiratory mucosal vaccines that
elicit both mucosal and systemic immune responses have garnered increasing attention …

The comparison of pathogenicity among SARS-CoV-2 variants in domestic cats

E Park, Y Kuroda, A Uda, Y Kaku, A Okutani, A Hotta… - Scientific Reports, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected or
isolated from domestic cats. It is unclear whether cats play an important role in the SARS …

Microparticle and nanoparticle-based influenza vaccines

L Ontiveros-Padilla, EM Bachelder… - Journal of Controlled …, 2024 - Elsevier
Influenza infections are a health public problem worldwide every year with the potential to
become the next pandemic. Vaccination is the most effective strategy to prevent future …

Early, robust mucosal secretory immunoglobulin A but not immunoglobulin G response to severe acute respiratory syndrome coronavirus 2 spike in oral fluid is …

N Pisanic, AAR Antar, MK Hetrich… - The Journal of …, 2025 - academic.oup.com
Background Efforts are underway to support the development of novel mucosal coronavirus
disease 2019 (COVID-19) vaccines. However, there is limited consensus about the …

Single MVA-SARS-2-ST/N vaccination rapidly protects K18-hACE2 mice against a lethal SARS-CoV-2 challenge infection

S Clever, L Limpinsel, C Meyer zu Natrup… - Viruses, 2024 - mdpi.com
The sudden emergence of SARS-CoV-2 demonstrates the need for new vaccines that
rapidly protect in the case of an emergency. In this study, we developed a recombinant MVA …

Subclinical SARS-CoV-2 infections and endemic human coronavirus immunity shape SARS-CoV-2 saliva antibody responses

TL Conner, E Goguet, H Haines-Hull, A Segard… - medRxiv, 2024 - medrxiv.org
This study characterized antibody responses induced by COVID-19 mRNA vaccination and
SARS-CoV-2 infection in saliva. Utilizing multiplex microsphere-based immunoassays, we …

[HTML][HTML] Urban wastewater contains a functional human antibody repertoire of mucosal origin

S Stephenson, W Eid, CH Wong, E Mercier… - Water Research, 2024 - Elsevier
Wastewater-based surveillance of human disease offers timely insights to public health,
hel** to mitigate infectious disease outbreaks and decrease downstream morbidity and …

Relationship Between Acute Severe Acute Respiratory Syndrome Coronavirus 2 Viral Clearance and Long Coronavirus 2019 (Long COVID) Symptoms: A Cohort …

C Herbert, AAR Antar, J Broach, C Wright… - Clinical Infectious …, 2024 - academic.oup.com
Background The relationship between severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) viral dynamics during acute infection and the development of long …