Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

The nuclear lamina is a key structural element of the metazoan nucleus. However, the
structural organization of the major proteins composing the lamina is poorly defined. Using …

Progenitor cells differentiate into specialized cell types through coordinated expression of
lineage-specific genes and modification of complex chromatin configurations. We …

Mechanical forces are known to influence cellular processes with consequences at the
cellular and physiological level. The cell nucleus is the largest and stiffest organelle, and it is …